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KMID : 0364519940060010041
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Dong-A Journal Medicine
1994 Volume.6 No. 1 p.41 ~ p.48
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The Effects of Subconjunctival Injection with Interferon Alpha-2a on Experimental corneal Neovascularization
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Abstract
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We investigated the effects of subconjunctival injection of interferon alpha-2a which is known to inhibit the endothelial cell proliferation and migration, on experimental vascularization in rabbits' eyes. Corneal stromal vascularization was
developed
in 16 pigmented rabbits by injecting sodium hydroxide(NaOH) into the corneal stroma. The rabbits were divided into three groups: rabbits were injected subconjunctivally with interferon alpha-2a at two weeks after NaOH injection, 150,000 IU/0.5cc
on
the
left eye(group A): subconjunctival injection of interferon at NaOH injection simultaneously, 150,000 IU/0.5cc on the both eyes(group B): normal saline, 0.5cc on the both eyes(control, group C). Rabbits received interferon injection three a week
for
6
weeks. Corneal photographs were taken weekly for 10 weeks and cornea stromal vascularization was quantified from photographs using digitizer. Interferon injected groups showed regression of neovascularization significantly compared with the
control:
group A from 3rd to 6th weeks(P<0.05). There is no difference between group A and B
Subconjunctival injection of interferon alpha-2a led to inhibition of neovascularization and regression of new vessels in experimental model of corneal neovascularization without severe side effects.
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KEYWORD
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